Candida Albicans: How it Affects the Pharmaceutical Industry
What is Candida albicans
Candida albicans is an opportunistic pathogenic yeast1 and a common member of human gut flora. It is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under certain conditions. It is one of the few species of the genus Candida that causes the human infection candidiasis, and a mortality rate of 40% has been reported for patients with systemic candidiasis due to Candida albicans2.
This article gives an overview of :
● The transfer of Candida albicans
● The detection, prevention and control of Candida albicans
● The risks of Candida albicans for consumers
● Treating Candida albicans
● Overview of industries affected by Candida albicans
● bioMérieux’s products and solutions for detecting and preventing Candida albicans
Prevention, Detection and Treatment
How is Candida albicans transferred?
Most infections due to Candida albicans result from a patient’s own microflora, rather than cross-infection, and it is not found in animal vectors3. It can also be transferred when there is existing microbial contamination of a product. Although rare, nosocomial transmission has also been reported to occur from inanimate surfaces, from the hands of healthcare workers or between patients4. Candida albicans 乐购彩票能赚钱吗is usually also transmitted from mother to infant through childbirth, and remains as part of a normal human’s microflora.
How can Candida albicans be prevented and controlled in the pharmaceutical industry?
Candida albicans infection can be prevented by maintaining a healthy lifestyle; good hygiene, proper nutrition, and careful antibiotic use prevent Candida albicans from outcompeting other commensal microorganisms. Immunocompromised individuals such as HIV, cancer, ICU, surgical, and transplant patients can experience recurrent infections or candidemia, but anti-fungal drugs can help in their situation.
Standard, comprehensive cleaning programs, in line with industry control guidelines, prevent the spread of Candida albicans in industrial environment.
How can the presence of Candida albicans be detected and controlled in the pharmaceutical industry?
Candida albicans乐购彩票能赚钱吗 is the most common fungal species isolated from biofilms either formed on (permanent) implanted medical devices or on human tissue. The condition candidemia is primarily diagnosed through blood cultures; however, in many cases, it becomes the obvious infection when antibiotics fail.
What are the risks of Candida albicans to the consumer?
Candida albicans is a commensal and opportunistic microorganism. In humans it can cause disease in immunodeficient and immunocompetent individuals that can be life-threatening. The most frequent clinical form is thrush/oral candidiasis, where infection can be observed on the tongue, palate or other mucosal surfaces and is characterized by single or multiple, ragged white patches.
The overgrowth of the Candida albicans fungus leads to symptoms of disease and occurs when there are imbalances in areas of the body – for example, changes in the normal acidity of the vagina. Candida albicans infections very rarely spread through sexual intercourse.
What is the treatment for Candida albicans contamination?
In the event of candidiasis the primary treatment for healthy adults is a drug called fluconazole (a triazole).
● Candida albicans is an opportunistic pathogenic yeast
● Candida albicans乐购彩票能赚钱吗 is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults
● Candida albicans乐购彩票能赚钱吗 is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under a variety of conditions
● A mortality rate of 40% has been reported for patients with systemic candidiasis due to Candida albicans
● Candida albicans is one of the Pharmacopeia microorganisms
● Candida albicans have been associated to non-sterile products contaminations
What common industries are affected by Candida albicans?
● Non-sterile Pharma & Personal Care
● Compounding and Hospital Pharmacy Solutions
● Advanced & Cellular Therapies Solutions
● Cell Therapy Manufacturers.
1 Gow, N.A.R. (2017). "Microbe Profile: Candida albicans: a shape-changing, opportunistic pathogenic fungus of humans". Microbiology. 163 (8): 1145–1147.
2 Singh, Rachna; Chakrabarti, Arunaloke (2017). "Invasive Candidiasis in the Southeast-Asian Region". In Prasad, Rajendra (ed.). Candida albicans: Cellular and Molecular Biology (2 ed.). Switzerland: Springer International Publishing AG. p. 27.
3 Public Health Agency of Canada. Candida albicans - Material Safety Data Sheets. [<http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/msds30e-eng.php]
4 Fanelloa S, Boucharab JP, Jousseta N, Delbosa V, LeFlohicc AM. 2001.
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